Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7687867 | TrAC Trends in Analytical Chemistry | 2018 | 68 Pages |
Abstract
For controlled release drug delivery applications, numerous PLGA based micro and nanospheres have been extensively studied. In order to describe the mechanisms involved during PLGA degradation, erosion and drug release from the bulk polymer, various mathematical models have been proposed. Along with describing the current state of art of mathematical modeling in drug dissolution, the review article addresses the role of autocatalysis in mass transport and chemical reaction phenomenon of drug delivery from polymeric drug delivery systems.
Keywords
FDAPLGASPSSPCLGITPLA2-Dnuclear magnetic resonancepoly lactic acidMANOVADrug releaseDrug dissolutionmultivariate analysis of varianceanalysis of varianceANOVANMRGastro-intestinal tracttwo dimensionalFood and Drug AdministrationMathematical modelingKinetic modelsPoly (lactic-co-glycolic) acidPolycaprolactone
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Ankush Parmar, Shweta Sharma,