Engineering design and mechanistic mathematical models: Standpoint on cutting edge drug delivery

For controlled release drug delivery applications, numerous PLGA based micro and nanospheres have been extensively studied. In order to describe the mechanisms involved during PLGA degradation, erosion and drug release from the bulk polymer, various mathematical models have been proposed. Along with describing the current state of art of mathematical modeling in drug dissolution, the review article addresses the role of autocatalysis in mass transport and chemical reaction phenomenon of drug delivery from polymeric drug delivery systems.