| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7688585 | TrAC Trends in Analytical Chemistry | 2016 | 59 Pages |
Abstract
- Solid-state protein investigations were performed.
- The lot-to-lot variabilities in lyophilized protein powders were determined.
- The molecular, particulate, and bulk properties of protein powders were studied.
- The structural properties and chemical stability of protein pharmaceuticals were explored.
- Analytical methods for batch-to-batch variability in lyophilized materials were proposed.
Keywords
APISAXSTGABJHNIRDEAIMCATRDVSAORAFMD2OTMADRSFDMTSDCMDSCESEMIGCWAXSDMADSCnuclear magnetic resonanceBrunauer–Emmett–TellerEscaH/DhGHDeuterated waterAnalytical toolsDESX-ray micro-computed tomographyOctTemBarrett–Joyner–HalendaAttenuated total reflectanceFourier transformThermogravimetric analysisThermomechanical analysisDielectric AnalysisDynamic mechanical analysisNMROptical coherence tomographyProcess analytical technologydynamic vapor sorptionFreeze dryingPowder propertiesglass transition temperatureRelative humiditycircular dichroismAngle of reposeBETElectron spectroscopy for chemical analysisDielectric relaxation spectroscopyDielectric spectroscopyPositron Annihilation Lifetime SpectroscopyX-ray photoelectron spectroscopyInfrared spectroscopyXPSNear infraredSEMActive Pharmaceutical IngredientScanning electron microscopyTransmission electron microscopyEnvironmental Scanning Electron Microscopyatomic force microscopyIsothermal microcalorimetryHuman growth hormonehydrogen/deuteriumpatPALSSmall-angle X-ray scatteringWide-angle X-ray scatteringTEADifferential scanning calorimetryModulated differential scanning calorimetryInverse gas chromatography
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Verena Wahl, Johannes Khinast, Amrit Paudel,