Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7688672 | TrAC Trends in Analytical Chemistry | 2016 | 28 Pages |
Abstract
Polymers were first introduced three decades ago as bioresorbable surgical devices. Since then, polymer-based nanoparticles have been extensively studied in a variety of fields. Nanocarriers formulated with biocompatible and biodegradable polymers approved by the US FDA (Food and Drug Administration) and EMA (European Medicines Agency) are being studied for the controlled delivery of various therapeutic agents. Amidst the various polymers synthesized for formulating polymeric nanoparticles, poly(lactic-co-glycolic acid) (PLGA) is the most popular. PLGA has several interesting properties such as controlled and sustained release, low cytotoxicity, long-standing biomedical applications, biocompatibility with tissues and cells, prolonged residence time and targeted delivery. The main aim of this review was to comprehensively address the issues related to PLGA-based nanoparticles focusing on the methods of preparation, characterization techniques, surface modification, mechanism of drug release and the drawbacks. The review also critically addresses the developmental aspects of PLGA-based nanocarriers in terms of targeted drug delivery, as well as exploring their efficacy in vitro and in vivo.
Keywords
VCAMPLAEMAGALTRESPNPDDSTPGSNHSDCCEGFRTechnetium 99mVEGFRP-gp99mTcN-hydroxysuccinimideN,N-dicyclohexylcarbodiimideFDAribose nucleic acidPLGAMDRPGAEDCMmpsnuclear magnetic resonanceDNAO/WP-glycoproteinsiRNAW/O/WSustained releaseEuropean Medicines agencyRNAdeoxyribose nucleic acidpolyglycolic acidMRIgut-associated lymphoid tissueFourier transform infraredNMREPRMagnetic resonance imagingglass transition temperatureoil in waterBiodegradableFood and Drug AdministrationDrug delivery systemReticuloendothelial systemmononuclear phagocyte systemFTIRX-ray photoelectron spectroscopyXPSMatrix metalloproteinasesMultidrug resistancevascular cell adhesion moleculeNanoparticlesPolymeric nanoparticleEnhanced permeability and retentionMPsTargetingpoly(lactic-co-glycolic acid)polyethylene glycolPolylactic acidPEGEpidermal growth factor receptorVascular endothelial growth factor receptors
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Shweta Sharma, Ankush Parmar, Shivpoojan Kori, Rajat Sandhir,