Advances in the application of chemiluminescence detection in liquid chromatography

Recently, chemiluminescence (CL)-based detection has become a very useful detection system in high-performance liquid chromatography (HPLC) due to its simplicity, low cost, high sensitivity and high selectivity. Some methods such as the use of photochemically induced CL reactions, the application of nanoparticles and new sample treatments have been combined either with well-known CL reactions based on the use of luminol, tris(2,2-bipyridine) ruthenium (II) and peroxyoxalate as CL precursors or with direct oxidations. This review presents some important contributions published during the last 5 years.