| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7689450 | TrAC Trends in Analytical Chemistry | 2015 | 9 Pages |
Abstract
Lipophilicity, quantified by the logarithm of the n-octanol/water partition coefficient (logP) or the distribution coefficient (logD), is a crucial parameter for modelling biological partition or distribution. As a maintream experimental method for lipophilicity measurement, reversed-phase high performance liquid chromatography (RP-HPLC) has attracted great interest and the attention of researchers throughout the world for its advantages including speed, reproducibility, insensitivity to impurities and degradation products, broad dynamic range, on-line detection, and reduced handling and sizes of samples. This review focuses on recent developments in lipophilicity measurement by RP-HPLC, both theoretical and experimental (mainly mobile and stationary phases).
Keywords
PS-DVBRP-TLCMLCHBCCCCPCBILCRTILCHIPBDEBMCOECDSfMRP-HPLCSSMODPPersistent organic pollutantIsocratic elutionQSPRQSARPolychlorinated biphenylPolybrominated BiphenylPolybrominated diphenyl etherQuantitative structure-activity relationshipGradient elutionQuantitative structure-activity relationshipsShake-flask methodPBBOrganization for Economic Co-operation and DevelopmentChromatographic hydrophobicity indexDistribution coefficientn-Octanol/water partition coefficientmass spectrometerImmobilized artificial membraneStationary phaseMobile phaseLipophilicityroom-temperature ionic liquidIAMpopPolystyrene-divinylbenzeneCounter-current chromatographyImmobilized liposome chromatographyreversed-phase high-performance liquid chromatographymicellar liquid chromatographyhigh-performance liquid chromatographyBiopartitioning micellar chromatography
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Chao Liang, Hong-zhen Lian,