Simulation of drug metabolism

Searching for more efficient, more economical methods for simulation of drug metabolism using in-vitro methodology is one of the most rapidly developing research areas in analytical chemistry. Due to the great progress in recent years, several different approaches are available to mimic the environment of hepatocytes - the site of drug metabolism in-vivo. These systems can be classified as: biocatalytical, electrochemistry-driven, electrochemical, chemical (free radical), and light-driven, and the computational models known as the in-silico approach. This review gives insight into these systems, highlighting the main trends and achievements.