| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7692472 | Chemistry and Physics of Lipids | 2013 | 13 Pages |
Abstract
⺠We simulated the spontaneous self-assembly of membrane protein and detergent. ⺠Four molecules of a membrane protein and 720 molecules of detergent in explicit water. ⺠Detergent self-aggregated into micelles, forming equatorial belts around the protein. ⺠Detergent micelles bound the protein's apical surfaces, mediating protein aggregation. ⺠Light scattering experiments support detergent-mediated protein aggregation.
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Authors
Chris Neale, Hamed Ghanei, John Holyoake, Russell E. Bishop, Gilbert G. Privé, Régis Pomès,