| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7692626 | Chemistry and Physics of Lipids | 2012 | 16 Pages |
Abstract
⺠The use of in situ self assembling (pro-nano) lipospheres is a suitable strategy to enhance the oral bioavailability of lipophilic drugs. ⺠Lipospheres can be utilized for drug administration via oral, ocular and parenteral routes. ⺠Some lipospheres advantages are: high stability and dispersibility, controlled particle size, high drug entrapment and extended release. ⺠The review focuses on preparation, physicochemical properties, in vitro evaluation and biopharmaceutical properties of lipospheres and PNL.
Keywords
AFMDSCDDSRESHLBSLNPNLTNBSnuclear magnetic resonanceAUCTrinitrobenzenesulfonic acidFatty acidX-ray diffractometryCSATemOral drug deliveryOcular drug deliveryDrug deliverytriglycerideNMRhydrophilic lipophilic balanceCNSdiglycerideEntrapment efficiencyPCsBCsDrug delivery systemReticuloendothelial systemBiopharmaceutical classification systemcentral nervous systemCyclosporine Aphoton correlation spectroscopyLoading capacityphosphatidylethanolamineLipospheresSEMarea under the curvemonoglycerideScanning electron microscopyTransmission electron microscopyatomic force microscopyBile saltXRDLaser diffractionDifferential scanning calorimetrygastro-intestinal
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Anna Elgart, Irina Cherniakov, Yanir Aldouby, Abraham J. Domb, Amnon Hoffman,