| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7692629 | Chemistry and Physics of Lipids | 2012 | 13 Pages |
Abstract
⺠Novel sphingolipid analogs inhibit the hydrolysis of ceramide or its conversion to complex sphingolipids. ⺠Synthetic analogs were effective in killing cancer cells in vitro and in vivo. ⺠Analogs were tested for two therapeutic approaches for sphingolipidoses: substrate reduction therapy and chaperone therapy. ⺠Synthetic fluorescent sphingolipids were developed for the analysis of sphingolipid metabolism.
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Authors
Shimon Gatt, Arie Dagan,