Article ID Journal Published Year Pages File Type
7692939 Chemistry and Physics of Lipids 2011 8 Pages PDF
Abstract
In contrast, chloro- and bromohydrins as well as dihalogenides are formed by the addition of HOCl or HOBr to the olefinic groups of the fatty acyl residues of lipids or under the influence of the enzyme myeloperoxidase (MPO) from Cl− and H2O2. We will show here by using MALDI-TOF MS for product analysis that halogenated products may also be generated in the presence of the Fenton reagent, if either FeCl2 or FeBr2 is used. In the presence of FeSO4, however, peroxides are exclusively generated. It will also be shown that the generation of halogen-containing products is a competing reaction with the cleavage of the double bond under generation of the corresponding aldehyde or carboxylic acid that is favored at prolonged incubation times and at elevated pH.
Related Topics
Physical Sciences and Engineering Chemistry Chemistry (General)
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