Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7693838 | Current Opinion in Chemical Biology | 2018 | 10 Pages |
Abstract
Great progress has been made in expanding the repertoire of genetically encoded fluorescent sensors for monitoring intracellular transition metals (TMs). This powerful toolkit permits dynamic and non-invasive detection of TMs with high spatial-temporal resolution, which enables us to better understand the roles of TM homeostasis in both physiological and pathological settings. Here we summarize the recent development of genetically encoded fluorescent sensors for intracellular detection of TMs such as zinc and copper, as well as heavy metals including lead, cadmium, mercury, and arsenic.
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Authors
Ziyang Hao, Rongfeng Zhu, Peng R Chen,