Article ID Journal Published Year Pages File Type
7693859 Current Opinion in Chemical Biology 2018 9 Pages PDF
Abstract
Time-dependent target occupancy is a function of both the thermodynamics and kinetics of drug-target interactions. However, while the optimization of thermodynamic affinity through approaches such as structure-based drug design is now relatively straight forward, less is understood about the molecular interactions that control the kinetics of drug complex formation and breakdown since this depends on both the ground and transition state energies on the binding reaction coordinate. In this opinion we highlight several recent examples that shed light on current approaches that are elucidating the factors that control the life-time of the drug-target complex.
Related Topics
Physical Sciences and Engineering Chemistry Chemistry (General)
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