Article ID Journal Published Year Pages File Type
7694581 Current Opinion in Chemical Biology 2015 7 Pages PDF
Abstract
Advances in mass spectrometry (MS) have transformed the scope and impact of protein characterization efforts. Identifying hundreds of proteins from rather simple biological matrices, such as yeast, was a daunting task just a few decades ago. Now, expression of more than half of the estimated ∼20 000 human protein coding genes can be confirmed in record time and from minute sample quantities. Access to proteomic information at such unprecedented depths has been fueled by strides in every stage of the shotgun proteomics workflow - from sample processing to data analysis - and promises to revolutionize our understanding of the causes and consequences of proteome variation.
Related Topics
Physical Sciences and Engineering Chemistry Chemistry (General)
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