| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7694743 | Current Opinion in Chemical Biology | 2014 | 9 Pages |
Abstract
The light-emitting chemical reaction catalyzed by the enzyme firefly luciferase is widely used for noninvasive imaging in live mice. However, photon emission from the luciferase is crucially dependent on the chemical properties of its substrate, D-luciferin. In this review, we describe recent work to replace the natural luciferase substrate with synthetic analogs that extend the scope of bioluminescence imaging.
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Chemistry (General)
Authors
Spencer T Jr., Stephen C Miller,