| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7694782 | Current Opinion in Chemical Biology | 2014 | 8 Pages |
Abstract
- Active site packing is critical for catalysis and is optimized by evolution.
- Tighter packing increases activity by preorganization, and not by desolvation.
- Directed evolution improves electrostatic preorganization.
- Mutations based on reorganization energy are in accord with evolved variants.
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Monika Fuxreiter, Letif Mones,