| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7694791 | Current Opinion in Chemical Biology | 2014 | 8 Pages |
Abstract
- Abasic lesions are transformed spontaneously and through enzyme catalyzed reactions into more deleterious forms of DNA damage.
- Abasic lesions for interstrand DNA cross-links.
- Oxidized abasic lesions irreversibly inactivate DNA polymerase β, a vital component of base excision repair.
- Histones catalyze DNA strand scission from abasic lesions and undergo lysine modification.
- Abasic site reactivity provides insight into the mechanism of action of DNA damaging agents that produce these lesions.
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Marc M Greenberg,