| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7695013 | Current Opinion in Chemical Biology | 2012 | 9 Pages |
Abstract
⺠Sirtuin NAD+-dependent deacetylation proceeds via a novel enzymatic mechanism. ⺠Deacetylation via an ADPR-imidate enables regulation by NAD+ and nicotinamide. ⺠Chemical probes of sirtuins have increased understanding of the imidate mechanism. ⺠Lysine acyl modifications beyond acetylation are deacylated by select sirtuins.
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Anthony A Sauve, Dou Yeon Youn,