| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7747417 | Coordination Chemistry Reviews | 2018 | 7 Pages |
Abstract
Increased drug resistance is associated to down-regulation of CTR1 and up-regulation of Cu-ATPases and Cu-chaperone Atox1, which is crucial for Cu secretion. The ability of Cu-lowering agents, such as tetrathiomolybdate, to increase cisplatin uptake, down-regulate Cu-ATPases and inhibit platination of Cu-Atox1 may resensitize cisplatin-resistant cells and improve the treatment efficacy of platinum drugs.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Fabio Arnesano, Maria I. Nardella, Giovanni Natile,