Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7747580 | Coordination Chemistry Reviews | 2018 | 12 Pages |
Abstract
Despite their past triumphs, platinum-based therapeutics remain limited by chemo-resistance and severe side effects. As an alternative therapeutic modality which bypasses these issues, photodynamic therapy (PDT) holds great promise. The first FDA approved PDT agent, Photofrin, stimulated an outpouring of porphyrin-motif studies, while metallodrugs have long been underappreciated in this area. Due to their unique and versatile properties, ruthenium complexes are receiving increasing attention in the field of PDT. Herein, we introduce the recent advances in Ru(II)-based PDT agents ranging from single molecules to delicate nanomaterials, how these agents are unique suited to PDT and the merits provided by their various forms.
Keywords
TPYbpyH2TPPDTPDMBPBBsDPBdppn2,3-Bis(2-pyridyl)pyrazinedppzDPPTPP1,10-Phenanthroline2,2′:6′,2″-Terpyridine2,2′-Bipyridine2,9-Dimethyl-1,10-phenanthroline4,4′-Dimethyl-2,2′-bipyridineTetraphenylporphyrinTriphenylphosphineBODIPYPhotodynamic therapySupramolecular systemsTAPPhenRuthenium(II) complexesNanomaterialsPiP
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Jiangping Liu, Chen Zhang, Thomas W. Rees, Libing Ke, Liangnian Ji, Hui Chao,