Artificial metalloenzymes as catalysts in non-natural compounds synthesis

The status of high-accuracy studies of metalloenzymes application as catalysts in non-natural compounds synthesis has been presented. The discussion is organized based on their stereo- and regioselectivities, as well as catalytic activities and the majority of these examples were reported within the last few years. Moreover computational methods, which are helpful for further development of new artificial metalloenzyme catalyst systems and explanation of the reaction mechanism, are discussed.