Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7750200 | Inorganica Chimica Acta | 2018 | 4 Pages |
Abstract
Targeted radionuclide therapy generally relies on the chelation of select short-lived isotopes such as 177Lu and 67Cu. The majority of Lu(III) and Cu(II) chelate structural information is derived from solid state diffraction data. Herein, the complexes Lu(DOTA)â, Cu(NOTA)â were examined in solution using EXAFS for the first time. Both ligands were fully deprotonated and coordinated to the metal with four and three carboxylic sites for Lu(DOTA)â and Cu(NOTA)â, respectively. Near-neighbor correlations from nitrogen atoms on the macrocyclic cages were also visible in the spectra in addition to the adjacent carbon backbones. Coordination numbers, bond distances, and Debye-Waller factors are reported and discussed alongside differences with known crystal structures.
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
M. Alex Brown, Thomas Brossard, David A. Rotsch,