| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7751238 | Inorganica Chimica Acta | 2015 | 13 Pages |
Abstract
Six Pt(IV) bis(aromatic carboxylato) anticancer prodrugs based on cisplatin or oxaliplatin were tested for their antiproliferative activity against several cancer cell lines. They resulted very potent, but barely soluble in water. Inclusion systems containing β-cyclodextrin and the prototype [Pt(NH3)2Cl2(C6H5COO)2] have been characterized and tested on the same cell lines.
Keywords
accumulation ratioESI-MSHEPESIC50HPLC-MSRP-HPLCMPMFBSDMEMUV-VisPBSICP-OESPo/wK′DLS4-(2-hydroxyethyl)-1-piperazineethanesulfonic acidDMSOElectrospray Ionization Mass SpectrometryCellular accumulationNMRDimethyl sulfoxideROESYRetention timefetal bovine serumDACHCyclodextrincyclodextrinsselectivity indexOctanol-water partition coefficientrotating frame Overhauser effect spectroscopyinductively coupled plasma-mass spectrometryhigh-performance liquid chromatography-mass spectrometryNuclear magnetic resonance spectroscopyultraviolet-visible spectroscopyInductively coupled plasma-optical emission spectroscopyICP-MSResistance factorPhosphate buffered salineAntiproliferative activityLipophilicityDulbecco’s modified eagle’s mediumMalignant pleural mesotheliomaRoswell Park Memorial Institute mediumQuantum mechanicsStability constantDynamic Light ScatteringGlassy carbonreverse-phase high-performance liquid chromatography
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Mauro Ravera, Elisabetta Gabano, Sabrina Bianco, Giuseppe Ermondi, Giulia Caron, Maura Vallaro, Giorgio Pelosi, Ilaria Zanellato, Ilaria Bonarrigo, Claudio Cassino, Domenico Osella,