| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7751448 | Inorganica Chimica Acta | 2013 | 29 Pages |
Abstract
Five copper complexes of Schiff-base condensates from 5-substituted-2-hydroxy-benzaldehyde and 2-substituted-benzenamine were synthesized and characterized. The copper complexes noncompetitively inhibit PTP1B, TCPTP, PTP-MEG2 and SHP-1, but do not inhibit SHP-2. Complex 5 exhibits very strong inhibition and better selectivity against PTP1B (IC50 = 0.059 μM).
Keywords
MOPSelectrospray ionization mass spectraTCPTPPTP1BSHP-2pNPPSHP-1CSDESI-MSPTPs3-morpholinopropanesulfonic acidSchiff baseSelective inhibitorMichaelis–Menten constantCopper complexesinhibition constantCambridge structural databaseT-cell protein tyrosine phosphataseprotein tyrosine phosphatasesProtein tyrosine phosphatase 1Bkapp
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Ruiting Zhu, Liping Lu, Miaoli Zhu, Hong Han, Caixia Yuan, Shu Xing, Xueqi Fu,