| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7751569 | Inorganica Chimica Acta | 2013 | 7 Pages |
Abstract
Ru-1 and Ru-2 were synthesized. The cytotoxicity of these complexes towards BEL-7402, HeLa, MCF-7 and MG-63 cells was evaluated by MTT method. The apoptosis was investigated by morphology and flow cytometry, cell cycle arrest was studied by flow cytometry. ROS and mitochondrial membrane potential were performed by fluorescence microscopy, and DNA-binding was investigated by electronic absorption titration.
Keywords
PBSES-MSMLCT2,7-dichlorofluorescein5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolcarbocyanine iodideJC-1RPMIDMPCtDNADcfFBS2,9-Dimethyl-1,10-phenanthroline3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromideDMSOCalf thymus DNAMTTDNA-bindingCell cycle arrestApoptosisDimethylsulfoxidefetal bovine serumCytotoxicity in vitroElectrospray mass spectroscopyRoswell Park Memorial InstituteRuthenium(II) complexesPhosphate-buffered salineMitochondrial membrane potentialPropidium iodide
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Yang-Yin Xie, Zheng-Zheng Li, Gan-Jian Lin, Hong-Liang Huang, Xiu-Zhen Wang, Zhen-Hua Liang, Guang-Bin Jiang, Yun-Jun Liu,