| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7751984 | Inorganica Chimica Acta | 2012 | 14 Pages |
Abstract
⺠Au(III)-t-butylsarcosinedithiocarbamato derivatives are potential anticancer agents. ⺠Slowly react with isolated dAMP but not with dGMP. ⺠Undergo sudden reduction to the gold(I) species in presence of GSH. ⺠Cytotoxic in vitro in the low micromolar range. ⺠Induce apoptosis and DNA fragmentation negligibly affecting cell cycle progression.
Keywords
DSCGSSGRPMIDAMPGSHHSADTCHEPESFITCtetramethylsilaneFBSPBSSARFACSdGMPTMS4-(2-hydroxyethyl)-1-piperazineethanesulfonic acidBSADMSOAlbuminhuman serum albuminbovine serum albuminenzyme-linked immunoadsorbent assayBrdUbromodeoxyuridineThermogravimetryELISAfluorescence-activated cell sortingdithiocarbamatesDithiocarbamatefetal bovine serumGoldPhosphatidylserineAnticancer activityfluorescein isothiocyanatePhosphate-buffered salineNucleotidesHMBC یا Heteronuclear Multiple Bond Correlationheteronuclear multiple bond correlationPropidium iodideDifferential scanning calorimetryGlutathione
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Giulia Boscutti, Lisa Feltrin, Debora Lorenzon, Sergio Sitran, Donatella Aldinucci, Luca Ronconi, Dolores Fregona,