| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7752176 | Inorganica Chimica Acta | 2012 | 10 Pages |
Abstract
⺠A series of fluorescein-based metal-binding compounds are presented. ⺠Boronate ester prochelators react with H2O2 to give fluorescent chelators. ⺠Fe3+ and Cu2+ quench chelator fluorescence, while Ni2+, Co2+, and Zn2+ less so. ⺠Cell-permeable prochelator FloB-SI responds to H2O2 by a decrease in fluorescence. ⺠FloB-SI response in cells suggests intracellular metal binding after H2O2 stress.
Keywords
HRMSDMEMNTASIHsalicylaldehyde isonicotinoyl hydrazoneFACFLOXHEPES4-(2-hydroxyethyl)-1-piperazineethanesulfonic acidDulbecco’s modified Eagle mediumROSIronFerric Ammonium CitrateEDTAEthylenediaminetetraacetic acidnitrilotriacetic acidOxidative stressminimal essential mediumMetal sensorhigh-resolution mass spectrometryFluorescenceMEMCopperHelaReactive oxygen species
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Lynne M. Hyman, Katherine J. Franz,