| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7753170 | Journal of Fluorine Chemistry | 2014 | 8 Pages |
Abstract
Introduction of a “click” 4-[N-(4-fluorobutyl)-(1,2,3-triazolyl)] group in Rimonabant-type pyrazoles produced a novel class of nanomolar CB1 receptor ligands for future [18F]radiofluorination. Molecule 1d is the most promising lead with a Ki CB1Â =Â 23Â nM.
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
![Pyrazoles with a “click” 4-[N-(4-fluorobutyl)-1,2,3-triazole] substituent in position 3 are nanomolar CB1 receptor ligands](/preview/png/7753170.png "First Page Preview: Pyrazoles with a “click” 4-[N-(4-fluorobutyl)-1,2,3-triazole] substituent in position 3 are nanomolar CB1 receptor ligands")
Authors
Rita Distinto, Chiara Zanato, Serena Montanari, Maria Grazia Cascio, Paolo Lazzari, Roger Pertwee, Matteo Zanda,