| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7753191 | Journal of Fluorine Chemistry | 2014 | 5 Pages |
Abstract
Ribonucleotide (RNA) analogs potentially stable to enzymatic hydrolysis were prepared and characterized. Computational investigations and DNA polymerase assay revealed that this class of compounds with a modified triphosphate with bridging difluoromethyl groups exhibits the correct polarity and minimal steric effects compared to the natural molecule.
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Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Anton Shakhmin, John-Paul Jones, Inessa Bychinskaya, Mikhail Zibinsky, Keriann Oertell, Myron F. Goodman, G.K. Surya Prakash,