Excessive zinc chloride induces murine photoreceptor cell death via reactive oxygen species and mitochondrial signaling pathway

High level ZnCl2 induces murine photoreceptor cells to generate excessive reactive oxygen species and cytochrome c release, decrease ATP production, collapse mitochondrial membrane potential, disrupt the balance between BCL2-associated X and B cell CLL/lymphoma 2, finally initiate mitochondria-mediated apoptotic signaling pathway, leading to cell death.224