| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7753624 | Journal of Inorganic Biochemistry | 2018 | 48 Pages |
Abstract
Interactions of abiraterone and galeterone with sterol 14α-demethylase (cytochrome P450 51A1, CYP51A1) were studied by absorbance spectroscopy, electrochemical methods and molecular docking. Both compounds induced type I binding spectra of CYP51A1. While only abiraterone behaved as a substrate in the electrochemical system, mass-spectrometric analysis revealed monohydroxylation of both compounds.301
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Inorganic Chemistry
Authors
Rami Masamrekh, Alexey Kuzikov, Alexander Veselovsky, Iliya Toropygin, Tatsiana Shkel, Natalia Strushkevich, Andrei Gilep, Sergey Usanov, Alexander Archakov, Victoria Shumyantseva,