Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7753662 | Journal of Inorganic Biochemistry | 2018 | 9 Pages |
Abstract
Six novel polypyridyl Ru(II) complexes have been found to bind DNA very tightly through intercalation and serve as high efficient DNA transcription and topoisomerase inhibitors. They have moderate cytotoxicity towards four tumor cell lines but very low cytotoxicity to normal cell, suggesting good potential as antitumor drugs.92
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Guo-Lan Ma, Xu-Dan Bi, Feng Gao, Zheng Feng, Dong-Chun Zhao, Feng-Jie Lin, Ru Yan, Dandan Liu, Peng Liu, Jingbo Chen, Hongbin Zhang,