Bifunctional 3-hydroxy-4-pyridinones as effective aluminium chelators: synthesis, solution equilibrium studies and in vivo evaluation

Sequestering ability of a set of extrafunctionalized 3-hydroxy-4-pyridinones (L1: 4-(3-hydroxy-2-methyl-4-oxopyridin-1(4H)-yl)butanoic acid; L2: (S)-2-amino-4-((2-(3-hydroxy-2-methyl-4-oxopyridin-1(4H)-yl)ethyl)amino)-4-oxobutanoic acid; L3: (S)-2-amino-4-((3-(3-hydroxy-2-methyl-4-oxopyridin-1(4H)-yl)propyl)amino)-4-oxobutanoic acid; L4: (S)-2-amino-5-(3-hydroxy-2-methyl-4-oxopyridin-1(4H)-yl)pentanoic acid; L5: 1-(3-aminopropyl)-3-hydroxy-2-methylpyridin-4(1H)-one) towards Al3+ in aqueous solution (pH = 4) and in vivo excretion capacity in animal model (mice overload with 67Ga).74