Hydrolysis reaction promotes changes in coordination mode of Ru(II)/acylthiourea organometallic complexes with cytotoxicity against human lung tumor cell lines

Ru(II)-arene complexes with acylthiourea ligands showed unusual coordination modes, either (S)-monodentate or (S,N)-bidentate, where the latter is the hydrolysis product of the former coordination situation. Two complexes are the first crystallographically ruthenium compounds with acylthiourea coordinated via S,N(amide) atoms. All complexes showed expressive cytotoxicity, interact with DNA and induced apoptosis.376