| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7753780 | Journal of Inorganic Biochemistry | 2018 | 52 Pages |
Abstract
Easily accessible enantiopure ruthenium compounds RRuRN-(1S,4R)- and SRuSN-(1R,4S)-[(η6-p-cymene)Ru{ĸNH(Bn),ĸNOH}Cl]Cl (Bn = benzyl, 1a and 1aâ²) are reported. Both isomers exhibit potent cytotoxicities in a variety of different cancer cell lines. Evaluation of 1a in a preliminary in vivo assay of PC-3 xenografts in nude mice resulted in an inhibition of tumor growth by 45%.188
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Isabel de la Cueva-Alique, Sara Sierra, Laura Muñoz-Moreno, Adrián Pérez-Redondo, Ana M. Bajo, Isabel Marzo, Lourdes Gude, Tomás Cuenca, Eva Royo,