| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7753785 | Journal of Inorganic Biochemistry | 2018 | 34 Pages |
Abstract
The new complexes 3a-d combine anti-cancer effects of naphthopyrans and a Ru(II) fragment. They bind to DNA 10 times faster and differently than cisplatin, and target the microtubular cytoskeleton causing mitotic arrest and antivascular effects. While active against cancer cells at nanomolar IC50 concentrations they do not affect non-malignant fibroblasts.260
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Florian Schmitt, Jana Kasparkova, Viktor Brabec, Gerrit Begemann, Rainer Schobert, Bernhard Biersack,