| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7753796 | Journal of Inorganic Biochemistry | 2018 | 42 Pages |
Abstract
Cytochrome P450 (CYP) 2J2 is responsible for the metabolism of the endocannabinoid, anandamide, into cardioprotective epoxides. We investigated the metabolism of six phytocannabinoids by CYP2J2. CYP2J2 mainly produces 1â²/1â³-OH metabolites of these phytocannabinoids. We determined that the phytocannabinoids are potent noncompetitive inhibitors of anandamide metabolism, with Î9-tetrahydrocannabinol being the strongest.294
Keywords
eCBΔ8-THCCarboxyNanodiscCytochrome P450 2J2CBGtetrahydrocannabinolCBCΔ9-THCAEACBRPCBCyPCBDCBNcannabigerolECsLC-MS/MSanandamideendocannabinoidCPRArachidonic acidepoxyeicosatrienoic acidPolyunsaturated fatty acidPUFAendocannabinoidsEETcytochrome P450 reductaseCytochrome P450endocannabinoid systemLiquid chromatography-tandem mass spectrometryHydroxyCannabidiolCannabinoidscannabinolcannabichromenecannabinoid receptor
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
William R. Arnold, Austin T. Weigle, Aditi Das,