| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7753820 | Journal of Inorganic Biochemistry | 2018 | 28 Pages |
Abstract
Frataxin (FXN) binds one Fe2+; the Fe2+-FXN complex is stabilized by its interaction with the scaffold protein (ISCU) on cysteine desulfurase. Upon the addition of reduced ferredoxin (Red-FDX) and l-cysteine, ferredoxin is oxidized (Ox-FDX), l-cysteine is converted to l-alanine generating sulfur, Fe2+ is oxidized to Fe3+, Fe-S binds to ISCU.68
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Kai Cai, Ronnie O. Frederick, Marco Tonelli, John L. Markley,