Membrane-attached mammalian cytochromes P450: An overview of the membrane's effects on structure, drug binding, and interactions with redox partners

Mammalian cytochromes P450 (CYPs) are membrane-attached proteins involved in many biotransformation processes in endoplasmic reticulum and mitochondria. Membranes affect CYP behavior which may alter the pattern of access/egress channels opening and substrate/metabolite transport into/from the buried CYP's active site as well as interaction with redox partners driven by electrostatic interactions.342