Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7753912 | Journal of Inorganic Biochemistry | 2018 | 54 Pages |
Abstract
The full coupling of the second step of Nitric Oxide Synthase reaction is achieved by tunneling of the cofactor tetrahydrobiopterin electron to the protonated Compound II singlet (Cpd II-P), which raises the side reaction barrier. In the absence of this electron tunneling, uncoupling leading to toxic species becomes equally possible.154
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Igor Shamovsky, Graham Belfield, Richard Lewis, Frank Narjes, Lena Ripa, Christian Tyrchan, Lisa Ãberg, Peter Sjö,