| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7753921 | Journal of Inorganic Biochemistry | 2018 | 9 Pages |
Abstract
The research revealed that RTHLVFFARK-NH2 (RK10) effectively inhibits β-amyloid (Aβ) aggregation and selectively chelates Cu2+ with high affinity, thus arresting Cu2+-catalyzed generation of reactive oxygen species. The bifunctional and highly selective features make the decapeptide promising as an agent against Cu2+-mediated Aβ aggregation for treatment of Alzheimer's disease.73
Related Topics
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Inorganic Chemistry
Authors
Jie Meng, Huan Zhang, Xiaoyan Dong, Fufeng Liu, Yan Sun,