Comparative studies on DNA-binding and in vitro antitumor activity of enantiomeric ruthenium(II) complexes

Molecular docking models of energy-minimized structure of DNA dodecamer duplex, d(CGCGAATTCGCG)2 with Δ-[Ru(bpy)2PBIP]2 + {bpy = 2,2′-bipyridine, PBIP = 2-(4-bromophenyl)imidazo[4,5-f]1,10-phenanthroline} (A) and Λ-[Ru(bpy)2PBIP]2 + (B). Both enantiomers intercalate between base pairs of DNA in minor groove, and that the Δ form intercalates into DNA more deeply than the Λ form does.251