| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7754080 | Journal of Inorganic Biochemistry | 2018 | 25 Pages |
Abstract
Antimicrobial phenanthroline-based copper(II) complexes induce necrotic cell death by oxidative stress. Ruthenium(II) complexes demonstrate lower cytotoxicity and lower antimicrobial activity. Despite established DNA binding activity, these complexes do not induce significant G2/M cell cycle arrest or genotoxicity, in comparison to covalent DNA binding drugs cisplatin and etoposide.135
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Neville S. Ng, Ming J. Wu, Janice R. Aldrich-Wright,