| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7754098 | Journal of Inorganic Biochemistry | 2018 | 14 Pages |
Abstract
Five platinum(IV) prodrugs conjugated with lonidamine (LND) were prepared. Pt(NH3)2(LND)Cl3 achieved improved anticancer activity against LNCaP cells and could trigger cancer cell death via an apoptotic pathway. And the apoptosis of LNCaP cells is closely associated with mitochondrial function disruption and reactive oxygen species accumulation.117
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Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Hong Chen, Feihong Chen, Weiwei Hu, Shaohua Gou,