| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7754376 | Journal of Inorganic Biochemistry | 2017 | 24 Pages |
Abstract
Replacing the ammine ligands on the cytotoxic monofunctional platinum complex pyriplatin, with a bidentate ethane-1,2-diamine ligand drastically reduces the potency. We have found that this structural change significantly affects the cellular uptake profile, and we have further investigated these differences by applying size exclusion chromatography inductively-coupled plasma mass spectrometry (SEC-ICP-MS).112
Keywords
PBSCTR1SECDLD-1dsDNAssDNAEtBrBSACt-DNAHuman colon adenocarcinomabovine serum albuminethidium bromidesingle-stranded deoxyribonucleic aciddouble-stranded deoxyribonucleic acidanalysis of varianceANOVACopper transporter 1inductively coupled plasma mass spectrometryICP-MSPhosphate buffered salineSize exclusion chromatographyhigh performance liquid chromatographyHPLC
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Marcus E. Graziotto, Mia C. Akerfeldt, Adam P. Gunn, Kylie Yang, Mark V. Somerville, Nicholas V. Coleman, Blaine R. Roberts, Trevor W. Hambley, Elizabeth J. New,