| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7754479 | Journal of Inorganic Biochemistry | 2016 | 4 Pages |
Abstract
Possible incorporation into RNA of the NTPs platinated model [Pt(dien)(N7-5â²-GTP)] (dien = diethylenetriamine; GTP = 5â²-guanosine triphosphate) has been studied. The inability of the model T7 RNA polymerase to use platinated nucleotides as substrates has been assessed. Our results suggest new pharmacological strategies to specifically target DNA, without affecting RNA.79
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Michele Benedetti, Alessandro Romano, Federica De Castro, Chiara R. Girelli, Daniela Antonucci, Danilo Migoni, Tiziano Verri, Francesco P. Fanizzi,