Effective cleavage of phosphodiester promoted by the zinc(II) and copper(II) inclusion complexes of β-cyclodextrin

Zinc(II) and copper(II)-β-cyclodextrin inclusion complexes were synthesized and characterized by X-ray crystallography. The catalytic kinetics of bis(4-nitrophenyl) phosphate hydrolysis were examined. Zinc inclusion complex can effectively cleave PO bond. The second-order rate constant of di-hydroxo zinc species was approximately an order of magnitude higher than those of reported mono-Zn(II)-hydroxo species.82