| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7754532 | Journal of Inorganic Biochemistry | 2016 | 8 Pages |
Abstract
The 1,3-dimethyl-N-boc-O-methylhistidin-2-ylidene ligand augments the cytotoxicity of metal fragments by increasing the cellular accumulation and by initiating distortion and unwinding of DNA. We identified a new platinum(II) complex which was cytotoxic against multidrug- and cisplatin-resistant cancer cells. In xenografted mice it was as active as cisplatin, yet better tolerated.48
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Florian Schmitt, Kate Donnelly, Julienne K. Muenzner, Tobias Rehm, Vojtech Novohradsky, Viktor Brabec, Jana Kasparkova, Martin Albrecht, Rainer Schobert, Thomas Mueller,