| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7754542 | Journal of Inorganic Biochemistry | 2016 | 10 Pages |
Abstract
A new polytopic ligand based in a poly-azamacrocyclic cyclophane (L3) is reported. Coordination of Mn2Â + for this new ligand and two related polytopic receptors was studied by potentiometric and paramagnetic NMR spectroscopy. A remarkable antioxidant activity was evidenced for these systems by the McCord-Fridovich assay and in Escherichiacoli sodAsodB deficient bacterial cells. The three ligands were tested as anti-inflammatory drugs in human macrophages measuring the accumulation of cytokines upon lipopolysaccharide (LPS) pro-inflammatory effect. All complexes showed anti-inflammatory effect.57
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Jorge González-GarcÃa, Ãlvar MartÃnez-Camarena, Begoña Verdejo, M. Paz Clares, Concepción Soriano, Enrique GarcÃa-España, Hermás R. Jiménez, Antonio Doménech-Carbó, Roberto Tejero, Enrique Calvo, Laura Briansó-Llort, Carolina Serena,