Cell cycle, apoptosis, cellular uptake and whole-transcriptome microarray gene expression analysis of HeLa cells treated with a ruthenium(II)-arene complex with an isoquinoline-3-carboxylic acid ligand

Analysis of the cellular and molecular response of HeLa cells to RuT7 complex indicate that, after inducing cell cycle arrest and triggering DNA repair mechanisms, it leads HeLa cells through the intrinsic (mitochondrial) apoptotic pathway, via indirect DNA damage made by the action of reactive oxygen species and through direct DNA binding131