| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7754669 | Journal of Inorganic Biochemistry | 2016 | 12 Pages |
Abstract
The cytotoxic compounds [(η6-cym)Ru(pqx)Cl]Cl and [(η6-cym)Ru(bpqx)Cl]Cl, (cym is 1-methyl-4-(1-methylethyl)benzene, pqx is 2-(2â²-pyridyl)quinoxaline and pbqx is 2-(2â²-pyridyl)benzo[g]quinoxaline), bind to the self-complementary oligonucleotide duplex d(5â²-CGCGCG-3â²)2 non-coordinatively, preserving their saturated coordination sphere (η6-arene-2N-Cl), causing elongation or disruption of the oligonucleotide Watson-Crick (W-C) hydrogen bonds.209
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Theodoros Tsolis, Konstantinos D. Papavasileiou, Spyridon A. Divanis, Vasilios S. Melissas, Achilleas Garoufis,